منابع مشابه
Synergistic interactions between kainate and mGlu receptors regulate bouton Ca2+ signalling and mossy fibre LTP
It is currently unknown why glutamatergic presynaptic terminals express multiple types of glutamate receptors. We have addressed this question by studying both acute and long-term regulation of mossy fibre function in the hippocampus. We find that inhibition of both mGlu₁ and mGlu₅ receptors together can block the induction of mossy fibre LTP. Furthermore, mossy fibre LTP can be induced by the ...
متن کاملTrafficking of Kainate Receptors
Ionotropic glutamate receptors (iGluRs) mediate the vast majority of excitatory neurotransmission in the central nervous system of vertebrates. In the protein family of iGluRs, kainate receptors (KARs) comprise the probably least well understood receptor class. Although KARs act as key players in the regulation of synaptic network activity, many properties and functions of these proteins remain...
متن کاملKainate receptors and synaptic transmission.
Excitatory glutamatergic transmission involves a variety of different receptor types, each with distinct properties and functions. Physiological studies have identified both post- and presynaptic roles for kainate receptors, which are a subtype of the ionotropic glutamate receptors. Kainate receptors contribute to excitatory postsynaptic currents in many regions of the central nervous system in...
متن کاملNomadic AMPA Receptors and LTP
leased glutamate could explain the electrophysiological changes observed during LTP that have been attributed to an increase in presynaptically released neurotrans-Long-term potentiation (LTP) is one of the most widely mitters. In support of the silent synapse hypothesis, studied topics in neuroscience today. LTP refers to a electrophysiological and immunohistochemical studies long-lasting incr...
متن کاملSynaptic plasticity of kainate receptors.
Synaptic plasticity of ionotropic glutamate receptors has been extensively studied with a particular focus on the role played by NMDA (N-methyl-D-aspartate) receptors in the induction of synaptic plasticity and the subsequent movement of AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptors. The third subtype of ionotropic glutamate receptor, kainate receptors, has not been ...
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ژورنال
عنوان ژورنال: Nature Reviews Neuroscience
سال: 2017
ISSN: 1471-003X,1471-0048
DOI: 10.1038/nrn.2017.34